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COA of HTL9936
Description:
HTL-9936 is a selective M1-receptor orthosteric partial agonist with EC50 of 32 nM and shows improved selectivity over M2- and M3-receptor subtypes. HTL 9936 also shows pro-cognitive activity in preclinical models.
Chemical Information
| Catalog | Featured products |
|---|---|
| Purity of current batch | >98% |
| CAS | 1438242-59-1 |
| Molecular Weight (MW) | 365.51 |
| Molecular Formula | C20H35N3O3 |
| Storage | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
Handling:
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Reference:
From structure to clinic: Design of a muscarinic
M1 receptor agonist with the potential
to treat Alzheimer’s disease-Brown et al., 2021, Cell 184, 5886–5901