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COA of ACBI3
Description:
ACBI3 is a selective, potent and in vivo active pan-KRAS PROTAC degrader, potently degrades 13 out of 17 of the most prevalent oncogenic KRAS alleles (DC50=3.9 nM in GP2d cells).
Chemical Information
| Catalog | Featured products |
|---|---|
| Purity of current batch | 98% |
| CAS | 2938169-76-5 |
| Molecular Weight (MW) | 1,019.260 |
| Molecular Formula | C50H62N14O6S2 |
| Storage | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
Handling:
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Reference:
Johannes Popow et al., Targeting cancer with small-molecule pan-KRAS degraders. Science (2024). DOI: 10.1126/science.adm8684 [2] Adrienne D. Cox and Channing J. Der. KRAS takes the road to destruction. Science (2024). DOI: 10.1126/science.ads2150[3] Kim, D., Herdeis, L., Rudolph, D. et al. Pan-KRAS inhibitor disables oncogenic signalling and tumour growth. Nature (2023). https://doi.org/10.1038/s41586-023-06123-3