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COA of LL-K12-18
Description:
LL-K12-18 is a highly potent dual-site molecular glue that induces the formation of the CDK12-DDB1 complex, exhibiting an EC50 of 0.37 nM. It demonstrates 80-fold greater potency than SR-4835 in MDA-MB-231 cells and a remarkable 307-fold increase in potency (EC50 = 0.03 nM) in MDA-MB-468 cells, while its degradation efficiency (DC50 = 0.38 nM) is 50-fold enhanced.
Chemical Information
| Catalog | Featured products |
|---|---|
| Purity of current batch | 98% |
| Molecular Weight (MW) | 559.49 |
| Molecular Formula | C25H32Cl2N10O |
| Storage | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
Handling:
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.