The TSCM-Ki Cocktail is a kinase inhibitor combination product validated through high-throughput screening. Its core function is to significantly increase the ratio of T memory stem cell (Tscm)-like cells—possessing self-renewal capacity and high persistence—in the final CAR-T cell product by transiently and reversibly modulating key kinase signaling pathways during the in vitroexpansion phase, thereby effectively preventing terminal T-cell differentiation. CAR-T cells manufactured using this product demonstrate superior tumor clearance capability and long-term immune memory in preclinical models.

Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Song, F., Tsahouridis, O., Stucchi, S., Walhart, T., Mendell, S., Hardy, P. B., Axtman, M., Guduru, S. K. R., Gilbert, T. S. K., Graves, L. M., Herring, L. E., Savoldo, B., Ma, X., Woodcock, M., Milner, J. J., Ivanova, A., Pearce, K. H., Xu, Y., & Dotti, G. (2025). A multi-kinase inhibitor screen identifies inhibitors preserving stem-cell-like chimeric antigen receptor T cells. Nature Immunology, 26, 279–293.