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COA of 2N12B
Description:
2N12B is a redox-responsive cationic lipid (pKa = 6.5) designed for siRNA delivery. Its LNPs mediate robust VEGFA knockdown in both cultured retinal cells and ex vivo mouse retina, while functionally impairing HUVEC motility. When administered in retinopathy models, the nanoparticles alleviate disease hallmarks including abnormal vessel growth and retinal vascular leakage.
Chemical Information
| Catalog | Cationic/Ionizable Lipids |
|---|---|
| Purity of current batch | >98% |
| CAS | 3067164-96-6 |
| Molecular Weight (MW) | 976.5 |
| Molecular Formula | C51H97N3O8S3 |
| Storage | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
Handling:
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.