CAP 2 is a unique ionizable lipid featuring a bicholesterol structure connected by a phosphate linker with an amino terminus. This design enables efficient in vivo delivery of both mRNA and saRNA via LNPs. In a Dmc1-deficient mouse model of male infertility, saRNA-encoded Dmc1 delivered by CAP 2 LNPs demonstrated prolonged protein expression in testicular tissue compared to mRNA formulations. The treatment restored spermatogenesis, improving germ cell maturation, seminiferous tubule morphology, and ultimately yielding functional sperm capable of fertilization.

Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.