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COA of DM4-SMCC
Description:
DM4-SMCC is an antibody-drug conjugate (ADC) payload that combines the potent antitubulin agent DM4 with a non-cleavable SMCC linker. This conjugate is designed to deliver cytotoxic effects specifically to tumor cells, leveraging DM4's ability to disrupt microtubule dynamics. The stable SMCC linker ensures controlled drug release, enhancing the ADC's antitumor activity while minimizing off-target toxicity.
Chemical Information
| Catalog | Drug-Linker Conjugates |
|---|---|
| Purity of current batch | >98% |
| CAS | 1228105-52-9 |
| Molecular Weight (MW) | 1114.69139385223 |
| Molecular Formula | C54H72CLN5O16S |
| Storage | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
Handling:
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.