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COA of MeTis Lipid 5
Description:
MeTis Lipid 5 is an ionizable lipid featuring a pyrazole-based headgroup and biodegradable C8-ester twin tails developed by MeTis Pharmaceuticals (Patent CN118290339B). It demonstrated breakthrough in vivo efficacy (7.08E+10 photons, luciferase assay), surpassing MC3 lipid by 8.8-fold in systemic mRNA delivery. The molecule achieves optimal safety-profile (96.4% cell viability) and encapsulation efficiency (96.4%), forming LNPs of 108.9 nm (PDI 0.17) at N/P 6. Its ester-enabled rapid metabolization and balanced hydrophobicity position lipid 5 as a candidate for next-gen mRNA therapeutics.
Chemical Information
| Catalog | Cationic/Ionizable Lipids |
|---|---|
| Purity of current batch | >98% |
| CAS | 3065967-73-6 |
| Molecular Weight (MW) | 870.36 |
| Molecular Formula | C45H89NO5 |
| Storage | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
Handling:
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.