Tidal Lipid 40is an ionizable cationic lipid engineered to deliver RNA with high precision to immune cells like macrophages. Based on ​​Tidal Therapeutics' patent US 20250205169A1​​, ​​ Its pH-responsive design shifts from a ​​+8 mV charge at pH 5.5​​ (enabling endosomal escape) to ​​near-neutral at pH 7.4​​ (reducing off -target binding), ensuring efficient intracellular release while maintaining blood stability. In lipid nanoparticles, Lipid 40 achieves ​​65% transfection efficiency in human macrophages​​—surpassing benchmarks like ALC-0315—and protects >95% of RNA payloads from degradation. Critically, it maintains particle integrity after freeze-thaw cycles with minimal size drift (<5 nm) and excels in in vivo targeting, driving potent gene expression in tumor-associated macrophages while avoiding liver/spleen accumulation. This combination of ​​precision delivery, stability, and low toxicity​​ makes it ideal for immunotherapies, such as reprogramming M2 macrophages to anti-tumor M1 states.

Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.