MOCHOL is an ionizable morpholine-modified cholesterol derivative. Unlike ordinary cholesterol that only stabilizes lipid bilayers, its tertiary amine head protonates in acidic endosomes to boost mRNA release via proton sponge effect. It reduces LNP hemolysis and serum lipid exchange, weakens hepatic tropism, and works compatibly with SM-102, AO12 and other ionizable lipids for extrahepatic mRNA delivery.

Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.