Description:
HGT5001, disclosed in patent US 2026/0125339 A1 by Translate Bio (now part of Sanofi), is a novel ionizable cationic lipid optimized for mRNA delivery. It enables efficient LNP assembly, high mRNA encapsulation, potent endosomal escape, and exceptional in vivo protein expression, with demonstrated efficacy in therapeutic mRNA applications, low toxicity, and favorable biocompatibility, making it a leading candidate for advanced mRNA therapeutics.
Handling:
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance,
we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one
month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at
least 1 hour.