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COA of Cobalt protoporphyrin IX chloride
Description:
Cobalt protoporphyrin IX (CoPPIX) is a potent and effective inducer of HO-1 (heme oxygenase-1) activity, up-regulates HO-1 via Bach1 and Nrf2 in human liver cells.CoPPIX did not influence hepatic Bach1 or Nrf2 mRNA levels, but markedly reduced Bach1 protein levels by increasing degradation of Bach1 protein, and increased Nrf2 by decreasing degradation of Nrf2 protein.CoPPIX significantly upregulated HO-1 protein in mucosal and submucosal cells.CoPPIX is a direct Bach1 inhibitor.
Chemical Information
| Catalog | Novel inhibitors |
|---|---|
| CAS | 102601-60-5 |
| Molecular Weight (MW) | 655.03 |
| Molecular Formula | C34H30ClCoN4O4.2H |
| Storage | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
Handling:
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.