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COA of BSJ-05-037
Description:
BSJ-05-037 is a potent and selective heterobifunctional degrader of ITK with DC50 of 17.6-41.8 nM in TCL lines DERL-2 and Hut78.
BSJ-05-037 induces potent degradation of ITK dependent on CRBN, neddylation, and the proteasome.
BSJ-05-037 induces GATA-3 loss and decreases chemotherapy resistance in vitro.
BSJ-05-037 disrupts TCR signaling, downregulates the Th2-associated transcription factor GATA-3, and can overcome chemotherapy resistance in TCL models in vivo.
Chemical Information
| Catalog | DC74479 |
|---|---|
| Purity of current batch | >98% |
| CAS | 2756388-01-7 |
| Molecular Weight (MW) | 1022.21 |
| Molecular Formula | C51H59N9O10S2 |
| Storage | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
Handling:
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Reference:
Jiang B, et al. Cell Chem Biol. 2023 Mar 27:S2451-9456(23)00086-7.