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COA of OICR41114
Description:
OICR41114 (PROTAC 4) is a WDR5-targeting PROTAC degrader. OICR41114 degrades endogenous WDR5 with an EC50 and Dmax values of 40 nM and 49%, respectively. OICR41114 degrades HiBiT-tagged WDR5 in a proteasome-dependent manner. OICR41114 is composed of target protein ligand Dimethyl-F-OICR-9429-COOH, E3 ligase ligand OICR-8268-acrylic acid and PROTAC linker Amino-PEG9-amine. The conjugate of E3 ligase ligand and linker is OICR-8268-acrylic acid-amino-PEG9-amine).
Chemical Information
| Catalog | Novel inhibitors |
|---|---|
| Molecular Weight (MW) | 1475.36 |
| Molecular Formula | C70H83Cl2F6N9O15 |
| Storage | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
Handling:
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.