PL1 is a novel biomimetic phospholipid. PL1 nanoparticle delivery of costimulatory receptor CD137 mRNA improved the immunotherapy with an anti-CD137 Ab to some extent in both tumor models with better results obtained in the B16F10 melanoma model as compared to the A20 lymphoma model.

Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Biomimetic nanoparticles deliver mRNAs encoding costimulatory receptors and enhance T cell mediated cancer immunotherapy-By: Li, Wenqing; Zhang, Xinfu ; Zhang, Chengxiang; Yan, Jingyue; Hou, Xucheng ; Du, Shi; Zeng, Chunxi; Zhao, Weiyu; Deng, Binbin; McComb, David W. ; et al Nature Communications (2021), 12(1), 7264 | Language: English, Database: CAplus and MEDLINE