API-1(NSC 177223) Datasheet DC Chemicals

Description	API-1 is a small-molecule Akt inhibitor that triggers Mcl-1 degradation through a GSK3/β-TrCP/FBXW7-dependent mechanism, ultimately promoting apoptotic cell death. In sensitive lung cancer models, API-1 treatment causes rapid Mcl-1 downregulation. Notably, forced Mcl-1 expression confers resistance to API-1-induced apoptosis.
Cat.No	DC60132
Name	API-1(NSC 177223)

Chemical Properties

CAS	36707-00-3
Formula	C13H15N5O6
MW	337.2881
Storage	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

References

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