Frutinone A, a bioactive flavanone isolated from Rhus species, exhibits significant cytotoxic, antimicrobial, and anti-inflammatory properties. Studies have shown that Frutinone A inhibits cancer cell proliferation with IC₅₀ values in the low micromolar range (e.g., ~5-10 µM in certain cancer cell lines). It also demonstrates antibacterial activity against Gram-positive bacteria like Staphylococcus aureus with MIC values around 10-25 µg/mL. Additionally, Frutinone A exerts anti-inflammatory effects by inhibiting nitric oxide (NO) production in LPS-stimulated macrophages with an IC₅₀ of approximately 15-20 µM. These bioactivities make it a potential lead compound for further pharmaceutical development.
