The TSCM-Ki Cocktail is a kinase inhibitor combination product validated through high-throughput screening. Its core function is to significantly increase the ratio of T memory stem cell (Tscm)-like cells—possessing self-renewal capacity and high persistence—in the final CAR-T cell product by transiently and reversibly modulating key kinase signaling pathways during the in vitroexpansion phase, thereby effectively preventing terminal T-cell differentiation. CAR-T cells manufactured using this product demonstrate superior tumor clearance capability and long-term immune memory in preclinical models.
Song, F., Tsahouridis, O., Stucchi, S., Walhart, T., Mendell, S., Hardy, P. B., Axtman, M., Guduru, S. K. R., Gilbert, T. S. K., Graves, L. M., Herring, L. E., Savoldo, B., Ma, X., Woodcock, M., Milner, J. J., Ivanova, A., Pearce, K. H., Xu, Y., & Dotti, G. (2025). A multi-kinase inhibitor screen identifies inhibitors preserving stem-cell-like chimeric antigen receptor T cells. Nature Immunology, 26, 279–293.
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