NEK7 degrader-3 Datasheet DC Chemicals

Description	NEK7 degrader-3 is an orally active and brain-penetrant NEK7 molecular glue degrader with a DC50 of 33.1 nM. NEK7 degrader-3 mediates interaction between NEK7 and E3 ligase cereblon, promoting proteasomal degradation of NEK7 and attenuating NLRP3 inflammasome-mediated inflammatory responses. NEK7 degrader-3 inhibits caspase-1 activity, cytokine release of IL-1β, IL-1α, and IL-18, and pyroptotic plasma membrane permeabilization. NEK7 degrader-3 shows antiinflammatory activity in an LPS-induced neuroinflammation mouse model. NEK7 degrader-3 can be used for the research of neuroinflammation.
Cat.No	DC81140
Name	NEK7 degrader-3

Chemical Properties

CAS	3094990-88-9
Formula	C26H24N6O2
MW	452.51
Storage	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

References

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