KT-253 Datasheet DC Chemicals

Description	KT-253 is a potent small molecule that stabilizes p53 while simultaneously acting as a PROTAC to degrade MDM2 (DC50 = 0.4 nM). It demonstrates strong antiproliferative effects in RS4;11 leukemia cells (IC50 = 0.3 nM), inducing G2/M cell cycle arrest and apoptosis. In vivo studies confirm its antitumor activity in mouse models.
Cat.No	DC65811
Name	KT-253

Chemical Properties

CAS	2713618-08-5
Formula	C48H52CL2FN7O6
MW	912.874193191528
Storage	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

References

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