YJ1206 Datasheet DC Chemicals

Description	YJ1206 is an orally bioavailable PROTAC compound that selectively degrades CDK12 and CDK13, demonstrating potent activity (IC50 = 12.55 nM) in VCaP cells. It induces DNA damage, triggers apoptosis, and drives tumor regression in treatment-resistant prostate cancer PDX models, highlighting its therapeutic potential.
Cat.No	DC67462
Name	YJ1206

Chemical Properties

CAS	3053716-98-3
Formula	C49H52FN11O5
MW	894.01
Storage	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

References

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