AC-55649 is a potent, highly isoform-selective agonist at the human RARβ2 receptor, with a pEC50 of 6.9[1]. AC-55649 is a potent and selective activator of RARβ2 transcriptional activity[2].
Kinase Assay
Cell Assay
Animal Administration
References
[1]. Lund BW, et al. Discovery of a potent, orally available, and isoform-selective retinoic acid beta2 receptor agonist. J Med Chem. 2005 Dec 1;48(24):7517-9.
[2]. Piu F, et al. Identification of novel subtype selective RAR agonists. Biochem Pharmacol. 2005 Dec 19;71(1-2):156-62.
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