CCS-1477(CBP-IN-1) Datasheet DC Chemicals

Description	CCS-1477 is a potent and selective p300/CBP bromodomain inhibitor, is targeted & differentiated from BET inhibitors in prostate cancer cell lines in vitro. Combination of CCS1477 & JQ1 resulted in a highly synergistic inhibitory effect on proliferation in normal 22Rv1 cells. Global gene expression analysis revealed significantly fewer altered genes after CCS1477 (27 up, 119 down) compared to JQ1 (196 up, 655 down).
Cat.No	DC31451
Name	CCS-1477(CBP-IN-1)

Chemical Properties

CAS	2222941-37-7
Formula	C30H32F2N4O3
MW	534.6078
Storage	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

References

[1]. Neil Anthony Pegg, et al. Pharmaceutical compounds. WO2018073586A1.

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