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CCS-1477(CBP-IN-1)

  Cat. No.:  DC31451   Featured
Chemical Structure
2222941-37-7
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More than 5000 active chemicals with high quality for research!
Field of application
CCS-1477 is a potent and selective p300/CBP bromodomain inhibitor, is targeted & differentiated from BET inhibitors in prostate cancer cell lines in vitro. Combination of CCS1477 & JQ1 resulted in a highly synergistic inhibitory effect on proliferation in normal 22Rv1 cells. Global gene expression analysis revealed significantly fewer altered genes after CCS1477 (27 up, 119 down) compared to JQ1 (196 up, 655 down).
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 2222941-37-7
Chemical Name: (S)-1-(3,4-difluorophenyl)-6-(5-(3,5-dimethylisoxazol-4-yl)-1-((1r,4S)-4-methoxycyclohexyl)-1H-benzo[d]imidazol-2-yl)piperidin-2-one
Synonyms: CCS-1477; CCS 1477; CCS1477;
SMILES: O=C1N(C2=CC=C(F)C(F)=C2)[C@H](C3=NC4=CC(C5=C(C)ON=C5C)=CC=C4N3[C@H]6CC[C@H](OC)CC6)CCC1
Formula: C30H32F2N4O3
M.Wt: 534.6078
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication: CCS1477: A Novel Small Molecule Inhibitor of p300/CBP Bromodomain for the Treatment of Acute Myeloid Leukaemia and Multiple Myeloma.---Blood (2019) 134 (Supplement_1): 2560.
Description: CCS-1477(CBP-IN-1) is a potent p300/CBP bromodomain inhibitor[1].
Target: p300/CBP[1]
References: [1]. Neil Anthony Pegg, et al. Pharmaceutical compounds. WO2018073586A1.
MSDS
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MSDS_13763_DC31451_2222941-37-7
COA
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