OTS186935 Datasheet DC Chemicals
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Cat.No DC11257
Name OTS186935

Chemical Properties

CAS 2093400-18-9
Formula C25H26CLN5O2
MW 463.966
Storage 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological activity

Description
Target: IC50: 6.49 nM (SUV39H2)[1]
In Vivo OTS186935 reveales significant inhibition of tumor growth in mouse xenograft models using MDA-MB-231 breast cancer cells and A549 lung cancer cells without any detectable toxicity[1].
In Vitro OTS186935 inhibits A549 cell growth with IC50 of 0.67 μM[1].
Kinase Assay
Cell Assay
Animal Administration

References

[1]. Vougiouklakis T, et al. Development of novel SUV39H2 inhibitors that exhibit growth suppressive effects in mouse xenograft models and regulate the phosphorylation of H2AX. Oncotarget. 2018 Aug 7;9(61):31820-31831.
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