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OTS186935

  Cat. No.:  DC11257   Featured
Chemical Structure
2093400-18-9
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More than 5000 active chemicals with high quality for research!
Field of application
OTS186935 (OTS-186935) is a potent, in vivo-active inhibitor of protein methyltransferase SUV39H2 with IC50 of 6.49 nM, inhibits A549 cell growth with IC50 of 0.67 uM; causes a significant growth inhibitory effect in mouse xenograft models using MDA-MB-231 breast cancer cells as well as A549 lung cancer cells, at 25 mg/kg once daily for 14 days yielded a TGI of 60.8%; attenuates the levels of H3K9me3 in A549 xenograft mouse model.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 2093400-18-9
Chemical Name: (S)-1-(2-(5-chloro-2,4-dimethoxyphenyl)imidazo[1,2-a]pyridin-7-yl)-N-(pyridin-4-ylmethyl)pyrrolidin-3-amine
Synonyms: OTS-186935;OTS 186935
SMILES: N(C1C=CN2C=C(C3=CC(Cl)=C(OC)C=C3OC)N=C2C=1)1CC[C@@H](NCC2C=CN=CC=2)C1
Formula: C25H26ClN5O2
M.Wt: 463.966
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication: 1. Vougiouklakis T, et al. Oncotarget. 2018 Aug 7;9(61):31820-31831.
Description: OTS186935 is a protein methyltransferase SUV39H2 inhibitor with an IC50 of 6.49 nM[1].
Target: IC50: 6.49 nM (SUV39H2)[1]
In Vivo: OTS186935 reveales significant inhibition of tumor growth in mouse xenograft models using MDA-MB-231 breast cancer cells and A549 lung cancer cells without any detectable toxicity[1].
In Vitro: OTS186935 inhibits A549 cell growth with IC50 of 0.67 μM[1].
References: [1]. Vougiouklakis T, et al. Development of novel SUV39H2 inhibitors that exhibit growth suppressive effects in mouse xenograft models and regulate the phosphorylation of H2AX. Oncotarget. 2018 Aug 7;9(61):31820-31831.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
Cat. No. Product name Field of application
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