MMV019313 Datasheet DC Chemicals

Description	MMV019313 (MMV 019313, MMV-019313) is a potent, specific malaria bifunctional farnesyl/geranylgeranyl diphosphate synthase (FPPS/GGPPS) inhibitor with IC50 of 330 nM; shows no activity against human FPPS or GGPPS (>200 uM); exhibits distinct modes of inhibition compared with bisphosphonates, inhibits P. falciparum growth with EC50 of 268 nM, overexpression and an S228T variant of PfFPPS/GGPPS confer resistance to MMV 019313.
Cat.No	DC11871
Name	MMV019313

Chemical Properties

CAS	902630-14-2
Formula	C22H27N3O2S
MW	397.537
Storage	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

References

References 1. Gisselberg JE, et al. Cell Chem Biol. 2017 Dec 15. pii: S2451-9456(17)30427-0. View Related Products by Target Parasite

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