MMV019313|MMV 019313|CAS 902630-14-2|DC Chemicals

Cas No.:	902630-14-2
Chemical Name:	N-[3-(azepan-1-yl)propyl]-5-methyl-4-oxothieno[3,2-c]quinoline-2-carboxamide
Synonyms:	MMV 019313;MMV-019313
SMILES:	N(C)1C2=C(C=CC=C2)C2SC(C(NCCCN3CCCCCC3)=O)=CC=2C1=O
Formula:	C₂₂H₂₇N₃O₂S
M.Wt:	397.537
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication:	1. Gisselberg JE, et al. Cell Chem Biol. 2017 Dec 15. pii: S2451-9456(17)30427-0.

Description:

MMV019313 (MMV 019313, MMV-019313) is a potent, specific malaria bifunctional farnesyl/geranylgeranyl diphosphate synthase (FPPS/GGPPS) inhibitor with IC50 of 330 nM; shows no activity against human FPPS or GGPPS (>200 uM); exhibits distinct modes of inhibition compared with bisphosphonates, inhibits P. falciparum growth with EC50 of 268 nM, overexpression and an S228T variant of PfFPPS/GGPPS confer resistance to MMV 019313.

References:

References 1. Gisselberg JE, et al. Cell Chem Biol. 2017 Dec 15. pii: S2451-9456(17)30427-0. View Related Products by Target Parasite

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101
2018-0101
2018-0101

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