Calmidazolium chloride (R 24571) Datasheet DC Chemicals
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Cat.No DC20021
Name Calmidazolium chloride (R 24571)

Chemical Properties

CAS 57265-65-3
Formula C31H23CL7N2O
MW 687.7
Storage 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological activity

Description CAS NO.：57265-65-3
Product Name：1H-Imidazolium,3-[bis(4-chlorophenyl)methyl]-1-[2-(2,4-dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]-,chloride (1:1)
Synonyms：1H-Imidazolium,3-[bis(4-chlorophenyl)methyl]-1-[2-(2,4-dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]-,chloride (1:1);1H-Imidazolium,3-[bis(4-chlorophenyl)methyl]-1-[2-(2,4-dichlorophenyl)-2-[(2,4-dichlorophenyl)...;Calmidazolium (chloride);Calmidazolium chloride;Calmidazolium chloride,1-[Bis(4-chlorophenyl)methyl]-3-[2-(2,4-dichlorophenyl)-2-(2,4-dichlorobenzyloxy)ethyl]-1H-imidazoliumchloride;NULL;R 24571;80 TRIHYDROCHLORIDE;Calimidazoline;CALMIDAZOLIUM;COMPOUND 48
EINEC:
Molecular Formula：C31H23CL7N2O
Molecular Weight：687.69812130928
Target: Kd: 3 nM (Calmodulin)[3]
In Vivo
In Vitro Calmidazolium chloride is widely used as a calmodulin (CaM) antagonist, but is also known to induce apoptosis in certain cancer cell lines. Calmidazolium chloride (3, 5, 7, 10 μM, 30 minutes-24 hours) inhibits growth of mouse F9 ECCs[2]. Cell Viability Assay[2] Cell Line: Mouse F9 ECCs Concentration: 3, 5, 7, 10 μM Incubation Time: 30 minutes-24 hours Result: The IC50s of Calmidazolium chloride treated F9 ECCs and E14 ESCs are 8.18 μM, and 12.69 μM[2].
Kinase Assay
Cell Assay
Animal Administration

References

[1]. Gietzen K, et al. Comparison of the calmodulin antagonists compound 48/80 and calmidazolium. Biochem J. 1983 Dec 15;216(3):611-6. [2]. Lee J, et al. Calmidazolium chloride inhibits growth of murine embryonal carcinoma cells, a model of cancer stem-like cells. Toxicol In Vitro. 2016 Sep;35:86-92. [3]. Budu A, et al. Calmidazolium evokes high calcium fluctuations in Plasmodium falciparum. Cell Signal. 2016 Mar;28(3):125-135.
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