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Calmidazolium chloride (R 24571)

  Cat. No.:  DC20021   Featured
Chemical Structure
57265-65-3
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Field of application
Calmidazolium chloride (R 24571) is a calmodulin (CaMK) antagonist, antagonizing CaM-dependent phosphodiesterase and calmodulin-induced activation of erythrocyte Ca2+-transporting ATPase with IC50s of 0.15 and 0.35 μM, respectively. Also in anti-cancer re
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 57265-65-3
Chemical Name: 1H-Imidazolium,3-[bis(4-chlorophenyl)methyl]-1-[2-(2,4-dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]-,chloride (1:1)
Synonyms: R 24571
SMILES: [Cl-].ClC1C=CC(COC(C2C=CC(Cl)=CC=2Cl)C[N+]2C=CN(C(C3C=CC(Cl)=CC=3)C3C=CC(Cl)=CC=3)C=2)=C(Cl)C=1
Formula: C31H23Cl7N2O
M.Wt: 687.7
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: Calmidazolium chloride (R 24571) is a calmodulin (CaMK) antagonist, antagonizing CaM-dependent phosphodiesterase and calmodulin-induced activation of erythrocyte Ca2+-transporting ATPase with IC50s of 0.15 and 0.35 μM, respectively[1]. Also in anti-cancer research[2]. Calmidazolium binds to CaMK with a Kd of 3 nM.
Target: Kd: 3 nM (Calmodulin)[3]
In Vitro: Calmidazolium chloride is widely used as a calmodulin (CaM) antagonist, but is also known to induce apoptosis in certain cancer cell lines. Calmidazolium chloride (3, 5, 7, 10 μM, 30 minutes-24 hours) inhibits growth of mouse F9 ECCs[2]. Cell Viability Assay[2] Cell Line: Mouse F9 ECCs Concentration: 3, 5, 7, 10 μM Incubation Time: 30 minutes-24 hours Result: The IC50s of Calmidazolium chloride treated F9 ECCs and E14 ESCs are 8.18 μM, and 12.69 μM[2].
References: [1]. Gietzen K, et al. Comparison of the calmodulin antagonists compound 48/80 and calmidazolium. Biochem J. 1983 Dec 15;216(3):611-6. [2]. Lee J, et al. Calmidazolium chloride inhibits growth of murine embryonal carcinoma cells, a model of cancer stem-like cells. Toxicol In Vitro. 2016 Sep;35:86-92. [3]. Budu A, et al. Calmidazolium evokes high calcium fluctuations in Plasmodium falciparum. Cell Signal. 2016 Mar;28(3):125-135.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
2018-0101
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