PF-719 Datasheet DC Chemicals

Description	PF-719 (PF719) is a potent, selective Pyk2 inhibitor with IC50 of 17 nM, displays 25-fold selectvity over FAK (IC50=469 nM); does not have significant inhibitory effects on recombinant MLCK2, p38, Akt1, or ROCK1, and very little inhibtion at Src family kinases (IC50>5 uM); selectively inhibits tyrosine phosphorylation of Pyk2 at 1 uM, but blocks both Pyk2 and FAK phosphorylation at 2.5 uM in A20 cells; reduces chemoattractant-induced migration of B-2 and MZ B cells.
Cat.No	DC21504
Name	PF-719

Chemical Properties

CAS	1404454-02-9
Formula	C22H29CL2F3N6O
MW	521.41
Storage	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

References

References 1. Tse KW, et al. Cell Immunol. 2012 Jan-Feb;275(1-2):47-54. View Related Products by Target Focal Adhesion Kinase (FAK)

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