PF-719 dihydrochloride|PF719|DC CHmeicals

Cas No.:	1404454-02-9
Chemical Name:	PF-719 dihydrochloride
Synonyms:	PF719
SMILES:	O=C(NC1CC1)C2=CC=C(NC3=NC=C(C(F)(F)F)C(N[C@H]4[C@H](N(C)C)CCC4)=N3)C=C2
Formula:	C₂₂H₂₉Cl₂F₃N₆O
M.Wt:	521.41
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication:	References 1. Tse KW, et al. Cell Immunol. 2012 Jan-Feb;275(1-2):47-54. View Related Products by Target Focal Adhesion Kinase (FAK)

Description:

PF-719 (PF719) is a potent, selective Pyk2 inhibitor with IC50 of 17 nM, displays 25-fold selectvity over FAK (IC50=469 nM); does not have significant inhibitory effects on recombinant MLCK2, p38, Akt1, or ROCK1, and very little inhibtion at Src family kinases (IC50>5 uM); selectively inhibits tyrosine phosphorylation of Pyk2 at 1 uM, but blocks both Pyk2 and FAK phosphorylation at 2.5 uM in A20 cells; reduces chemoattractant-induced migration of B-2 and MZ B cells.

References:

References 1. Tse KW, et al. Cell Immunol. 2012 Jan-Feb;275(1-2):47-54. View Related Products by Target Focal Adhesion Kinase (FAK)

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101
2018-0101

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