ZINC02092166 Datasheet DC Chemicals

Description	ZINC02092166 is a novel potent, and selective small-molecule inhibitor for the β-catenin/Tcf4 protein-protein interaction with Ki of 1.7 and 7.0 uM in AlphaScreen and FP assay (wild-type β-catenin), respectively; remain affinity for muant catenin V511S, V511S/I569S and R469A with Ki of 20-50 uM; exhibits dual selectivity for β-catenin/Tcf over β-catenin/cadherin and β-catenin/APC PPIs.
Cat.No	DC21852
Name	ZINC02092166

Chemical Properties

CAS	354543-09-2
Formula	C14H7N9O3
MW	349.26388001442
Storage	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

References

1. Catrow JL, et al. J Med Chem. 2015 Jun 11;58(11):4678-92.

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