| Cas No.: | 354543-09-2 |
| Chemical Name: | 4-amino-N'-{13-oxa-10,12,14,16-tetraazatetracyclo7.7.0.0^{2,7}.0^{11,15}hexadeca-1(16),2,4,6,9,11,14-heptaen-8-ylidene}-1,2,5-oxadiazole-3-carbohydrazide |
| Synonyms: | BDBM50094590;J3.583.511C;(E)-4-amino-N'-(9H-indeno[1,2-b][1,2,5]oxadiazolo[3,4-e]pyrazin-9-ylidene)-1,2,5-oxadiazole-3-carbohydrazide;(Z)-4-Amino-N'-(9H-indeno[1,2-b][1,2,5]oxadiazolo[3,4-e]pyrazin-9-ylidene)-1,2,5-oxadiazole-3-carbohydrazide;4-Amino-N'-(9H-indeno[1,2-b][1,2,5]oxadiazolo[3,4-e]pyrazin-9-ylidene)-1,2,5-oxadiazole-3-carbohydrazide;4-Amino-N'-[(9Z)-;Nc1nonc1C(=O)N\N=C1\c2ccccc2-c2nc3nonc3nc12;LQZ-7F;4-amino-N'-{13-oxa-10,12,14,16-tetraazatetracyclo7.7.0.0^{2,7}.0^{11,15}hexadeca-1(16),2,4,6,9,11,14-heptaen-8-ylidene}-1,2,5-oxadiazole-3-carbohydrazide |
| SMILES: | O1N=C2C(N1)=NC1=C(C3C=CC=CC=3C1=N2)/N=N/C(C1C(N)=NON=1)=O |
| Formula: | C14H7N9O3 |
| M.Wt: | 349.26388001442 |
| Purity: | >98% |
| Sotrage: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Publication: | 1. Catrow JL, et al. J Med Chem. 2015 Jun 11;58(11):4678-92. |
| Description: | ZINC02092166 is a novel potent, and selective small-molecule inhibitor for the β-catenin/Tcf4 protein-protein interaction with Ki of 1.7 and 7.0 uM in AlphaScreen and FP assay (wild-type β-catenin), respectively; remain affinity for muant catenin V511S, V511S/I569S and R469A with Ki of 20-50 uM; exhibits dual selectivity for β-catenin/Tcf over β-catenin/cadherin and β-catenin/APC PPIs. |
| References: | 1. Catrow JL, et al. J Med Chem. 2015 Jun 11;58(11):4678-92. |
MSDS
COA
| LOT NO. | DOWNLOAD |
|
|
|
| 2018-0101 |
|
| 2018-0101 |
|