IRES-J007 Datasheet DC Chemicals

Description	IRES-J007 ia an improved IRES inhibitor that blocks IRES-hnRNP A1 binding; binds to a small pocket structure within the RRM-containing fragment of hnRNP A1 (UP1 fragment), inhibits cyclin D1 and c-MYC IRES activity to a greater extent compared with C11 (IRES-C11); significantly reduces tumor growth of GBM xenografts in mice, and markedly reduces the mRNA translational state of cyclin D1 and c-MYC transcripts combined with PP242.
Cat.No	DC22995
Name	IRES-J007

Chemical Properties

CAS	155514-72-0
Formula	C17H15NO4
MW	297.3053
Storage	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

References

References 1. Holmes B, et al. J Biol Chem. 2016 Jul 1;291(27):14146-59. View Related Products by Target c-Myc

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