IRES-J007| CAS 155514-72-0|DC Chemicals

Cas No.:	155514-72-0
Chemical Name:	N-(2,4-Dimethoxybenzyl)phthalimide
Synonyms:	2-(2,4-dimethoxybenzyl)isoindoline-1,3-dione;N-(2,4-Dimethoxybenzyl)phthalimide;2-[(2,4-dimethoxyphenyl)methyl]isoindole-1,3-dione
SMILES:	O(C([H])([H])[H])C1C([H])=C(C([H])=C([H])C=1C([H])([H])N1C(C2=C([H])C([H])=C([H])C([H])=C2C1=O)=O)OC([H])([H])[H]
Formula:	C₁₇H₁₅NO₄
M.Wt:	297.3053
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication:	References 1. Holmes B, et al. J Biol Chem. 2016 Jul 1;291(27):14146-59. View Related Products by Target c-Myc

Description:

IRES-J007 ia an improved IRES inhibitor that blocks IRES-hnRNP A1 binding; binds to a small pocket structure within the RRM-containing fragment of hnRNP A1 (UP1 fragment), inhibits cyclin D1 and c-MYC IRES activity to a greater extent compared with C11 (IRES-C11); significantly reduces tumor growth of GBM xenografts in mice, and markedly reduces the mRNA translational state of cyclin D1 and c-MYC transcripts combined with PP242.

References:

References 1. Holmes B, et al. J Biol Chem. 2016 Jul 1;291(27):14146-59. View Related Products by Target c-Myc

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101
2018-0101

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