BRD7586 Datasheet DC Chemicals

Description	BRD-7586(BRD 7586) is a cell-permeable small molecule inhibitor of SpCas9 with EC50 of 6.2 µM and 5.7 µM in the eGFP-disruption and HiBiT-knock-in assays, respectively. BRD7586 specifically engages SpCas9 but not Cas12a in cells and enhances SpCas9 specificity at multiple loci.
Cat.No	DC60333
Name	BRD7586

Chemical Properties

CAS	895460-70-5
Formula	C17H14CLN3O3S2
MW	407.90
Storage	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

References

A general approach to identify cell-permeable and synthetic anti-CRISPR small molecules-Donghyun Lim, Qingxuan Zhou, etl. Nature Cell Biology volume 24, pages1766–1775 (2022)Cite this article

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