BRD7586

  Cat. No.:  DC60333   Featured
BRD7586
Chemical Structure
895460-70-5
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Field of application
BRD-7586(BRD 7586) is a cell-permeable small molecule inhibitor of SpCas9 with EC50 of 6.2  µM and 5.7  µM in the eGFP-disruption and HiBiT-knock-in assays, respectively. BRD7586 specifically engages SpCas9 but not Cas12a in cells and enhances SpCas9 specificity at multiple loci.
Cas No.: 895460-70-5
Chemical Name: BRD7586
Synonyms: Propanamide, 3-[(4-chlorophenyl)sulfonyl]-N -[4-(4-pyridinyl)-2- thiazolyl]- (ACI)
SMILES: O=C(NC1=NC(=CS1)C=2C=CN=CC2)CCS(=O)(=O)C3=CC=C(Cl)C=C3
Formula: C17H14ClN3O3S2
M.Wt: 407.90
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication: A general approach to identify cell-permeable and synthetic anti-CRISPR small molecules-Donghyun Lim, Qingxuan Zhou, etl. Nature Cell Biology volume 24, pages1766–1775 (2022)Cite this article
Description: BRD7586 is a cell-permeable small molecule inhibitor of SpCas9 with EC50 of 6.2  µM and 5.7  µM in the eGFP-disruption and HiBiT-knock-in assays, respectively. BRD7586 specifically engages SpCas9 but not Cas12a in cells and enhances SpCas9 specificity at multiple loci.
References: A general approach to identify cell-permeable and synthetic anti-CRISPR small molecules-Donghyun Lim, Qingxuan Zhou, etl. Nature Cell Biology volume 24, pages1766–1775 (2022)Cite this article
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