HbF inducer 2 Datasheet DC Chemicals

Description	HbF inducer 2 is an orally bioavailable molecular glue that selectively degrades the WIZ transcription factor (DC50 = 13 nM in human erythroid precursors) and upregulates fetal hemoglobin (HbF) expression (EC50 = 100 nM). By inducing WIZ proteolysis, it disrupts the γ-globin repressor complex, demonstrating promising pharmacokinetics in cynomolgus monkeys for potential β-hemoglobinopathy therapy.
Cat.No	DC67336
Name	HbF inducer 2

Chemical Properties

CAS	2654011-51-3
Formula	C21H27N3O4
MW	385.46
Storage	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

References

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