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HbF inducer 2

  Cat. No.:  DC67336   Featured
Chemical Structure
2654011-51-3
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More than 5000 active chemicals with high quality for research!
Field of application
HbF inducer 2 is an ​orally bioavailable molecular glue that selectively degrades the ​WIZ transcription factor (DC50 = 13 nM in human erythroid precursors) and upregulates ​fetal hemoglobin (HbF) expression (EC50 = 100 nM). By inducing WIZ proteolysis, it disrupts the ​γ-globin repressor complex, demonstrating promising ​pharmacokinetics in cynomolgus monkeys for potential ​β-hemoglobinopathy therapy.
Cas No.: 2654011-51-3
Chemical Name: 3-[6-[[(2R)-1-ethylpiperidin-2-yl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione
Synonyms: DWIZ-2;SCHEMBL23532590;EX-A9597;2654011-51-3
SMILES: O(C1C=CC2C(N(CC=2C=1)C1C(NC(CC1)=O)=O)=O)C[C@H]1CCCCN1CC
Formula: C21H27N3O4
M.Wt: 385.46
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
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