GSK-872 Datasheet DC Chemicals
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Cat.No DC10471
Name GSK-872

Chemical Properties

CAS 1346546-69-7
Formula C19H17N3O2S2
MW 383.49
Storage 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological activity

Description
Target:
In Vivo
In Vitro GSK'872 blocks necroptosis in mouse cells. RIP3i GSK'872 inhibits TLR3- or DAI-induced death, two RIP1-independent pathways of necroptosis[1]. Pretreatment with GSK'872 (GSK-872) confers significant protection to primary hepatocytes. However, RIPK1 inhibition (by Nec1) does not impart any protection to primary hepatocytes[2].
Kinase Assay
Cell Assay
Animal Administration

References

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