JNJ-7777120 Datasheet DC Chemicals
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Cat.No DC8773
Name JNJ-7777120

Chemical Properties

CAS 459168-41-3
Formula C14H16CLN3O
MW 277.7493
Storage 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological activity

Description CAS NO.：459168-41-3
Product Name：1-[(5-Chloro-1H-indol-2-yl)carbonyl]-4-methylpiperazine
Synonyms：Methanone,(5-chloro-1H-indol-2-yl)(4-methyl-1-piperazinyl)-;JNJ-7777120;(5-Chloro-1H-indol-2-yl)(4-methylpiperazin-1-yl)methanone;JNJ 7777120;Piperazine, 1-[(5-chloro-1H-indol-2-yl)carbonyl]-4-methyl-;(5-chloro-1H-indol-2-yl)-(4-methyl-piperazin-1-yl)methanone;(5-chloro-1H-indol-2-yl)-(4-methyl-piperazin-1-yl)-methanone;[3H]-JNJ-7777120;1-((5-chloro-1H-indol-2-yl)carbonyl)-4-methylpiperazine;1-[(5-chloro-1H-indol-2-yl)carbonyl]-4-methylpiperazine;1-[(5-CHLORO-1H-INDOL-2-YL)CARBONYL]-4-METHYL-PIPERAZINE;AC1NK6AJ;STK175446;JNJ7777120;HUQJRYMLJBBEDO-UHFFFAOYSA-N;4H1AU2V37X;(5-chloro-1H-indol-2-yl)-(4-methylpiperazin-1-yl)methanone;METHANONE, (5-CHLORO-1H-INDOL-2-YL)(4-
EINEC:
Molecular Formula：C14H16CLN3O
Molecular Weight：277.7493
Target:
In Vivo
In Vitro
Kinase Assay
Cell Assay
Animal Administration

References

[1]. Jablonowski JA, et al. The first potent and selective non-imidazole human histamine H4 receptor antagonists. J Med Chem. 2003 Sep 11;46(19):3957-3960. [2]. Rosa AC, et al. Prevention of bleomycin-induced lung inflammation and fibrosis in mice by naproxen and JNJ-7777120 treatment. J Pharmacol Exp Ther. 2014 Nov;351(2):308-316. [3]. Thurmond RL, et al. A potent and selective histamine H4 receptor antagonist with anti-inflammatory properties. J Pharmacol Exp Ther. 2004 Apr;309(1):404-413.
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