JNJ-7777120|cas 459168-41-3|DC Chemicals

Cas No.:	459168-41-3
Chemical Name:	1-[(5-Chloro-1H-indol-2-yl)carbonyl]-4-methylpiperazine
Synonyms:	Methanone,(5-chloro-1H-indol-2-yl)(4-methyl-1-piperazinyl)-;JNJ-7777120;(5-Chloro-1H-indol-2-yl)(4-methylpiperazin-1-yl)methanone;JNJ 7777120;Piperazine, 1-[(5-chloro-1H-indol-2-yl)carbonyl]-4-methyl-;(5-chloro-1H-indol-2-yl)-(4-methyl-piperazin-1-yl)methanone;(5-chloro-1H-indol-2-yl)-(4-methyl-piperazin-1-yl)-methanone;[3H]-JNJ-7777120;1-((5-chloro-1H-indol-2-yl)carbonyl)-4-methylpiperazine;1-[(5-chloro-1H-indol-2-yl)carbonyl]-4-methylpiperazine;1-[(5-CHLORO-1H-INDOL-2-YL)CARBONYL]-4-METHYL-PIPERAZINE;AC1NK6AJ;STK175446;JNJ7777120;HUQJRYMLJBBEDO-UHFFFAOYSA-N;4H1AU2V37X;(5-chloro-1H-indol-2-yl)-(4-methylpiperazin-1-yl)methanone;METHANONE, (5-CHLORO-1H-INDOL-2-YL)(4-
SMILES:	ClC1C([H])=C([H])C2=C(C=1[H])C([H])=C(C(N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])=O)N2[H]
Formula:	C₁₄H₁₆ClN₃O
M.Wt:	277.7493
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

JNJ-7777120 is a selective H4R antagonist with Ki of 4 ±1 nM, exhibits >1000-fold selectivity over the other histamin receptors.IC50 value: 4 ±1 nM (Ki) [1] Target: histamine H4 receptorin vitro: JNJ-7777120 prevents fibronectin-induced lung fibroblast migration, thus suggesting that H4R could represent an attractive target for the development of new drugs for lung fibrosis treatment .[2]in vivo: JNJ 7777120 blocks histamine-induced chemotaxis and calcium influx in mouse bone marrow-derived mast cells. In addition, it can block the histamine-induced migration of tracheal mast cells from the connective tissue toward the epithelium in mice. JNJ 7777120 significantly blocks neutrophil infiltration in a mouse zymosan-induced peritonitis model. [3]

References:

[1]. Jablonowski JA, et al. The first potent and selective non-imidazole human histamine H4 receptor antagonists. J Med Chem. 2003 Sep 11;46(19):3957-3960. [2]. Rosa AC, et al. Prevention of bleomycin-induced lung inflammation and fibrosis in mice by naproxen and JNJ-7777120 treatment. J Pharmacol Exp Ther. 2014 Nov;351(2):308-316. [3]. Thurmond RL, et al. A potent and selective histamine H4 receptor antagonist with anti-inflammatory properties. J Pharmacol Exp Ther. 2004 Apr;309(1):404-413.

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101
2018-0101

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