2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Biological activity
Description
CAS NO.：749886-87-1 Product Name：4-Methyl-N1-(3-phenylpropyl)benzene-1,2-diamine Synonyms：4-METHYL-N1-(3-PHENYLPROPYL)BENZENE-1,2-DIAMINE;JSH-23;LogP;4-Methyl-N1-(3-phenylpropyl)-1,2-phenylenediamine;4-methyl-1-N-(3-phenylpropyl)benzene-1,2-diamine;B Activation Inhibitor II, JSH-23;JSH 23;NF-κ4-methyl-N1-(3-phenylpropyl)-1,2-benzenediamine;AK175962;JSH23;4-Methyl-N~1~-(3-phenylpropyl)benzene-1,2-diamine;AOB2674;NF-kappaB activation inhibitor II;HMS3653C16;BCP09944;FD5025;IN1201;s7351;KS-0 EINEC: Molecular Formula：C16H20N2 Molecular Weight：240.3434
Target:
In Vivo
JSH-23 (1 and 3 mg/kg, p.o.) significantly reverses the nerve conduction and nerve blood flow deficits seen in diabetic animals and decreases the nerve lipid peroxidation, partially replenishes the depleted levels of GSH in nerve of diabetic rats[4].
In Vitro
JSH-23 inhibits lipopolysaccharide (LPS)-induced chromatin condensation in a dose-dependent manner, corresponding to 44±4% inhibition at 3 μM, 63±5% at 10 μM and 93±3% at 30 μM[1]. JSH-23 (5, 10, and 15 μM) significantly reduces mean neuronal migration in LPS-activated cells[2]. Co-treatment of A2780 cells with JSH-23 and clinically ineffective transplatin at their IC50 concentrations (130 μM transplatin and 20 μM JSH-23) for 72 h also causes a more pronounced decrease in cell viability compared to the effects of transplatin or JSH-23 alone[3].
Kinase Assay
Cell Assay
Animal Administration
References
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