NU2058 Datasheet DC Chemicals
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Cat.No DC10734
Name NU2058

Chemical Properties

CAS 161058-83-9
Formula C12H17N5O
MW 247.3
Storage 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological activity

Description
Target: CDK2:17 μM (IC50) CDK1:26 μM (IC50)
In Vivo
In Vitro NU2058 is a competitive inhibitor of CDK2 with respect to ATP (Ki value CDK2, 12 3 μM) that binds in the ATP binding pocket in a different orientation from other purine-based inhibitors, including olomoucine and roscovotine. NU2058 is the lead compound in a structure-based drug discovery program to develop more potent and selective CDK inhibitors.
Kinase Assay
Cell Assay
Animal Administration

References

[1]. Rigas AC, et al. Therapeutic potential of CDK inhibitor NU2058 in androgen-independent prostate cancer. Oncogene. 2007 Dec 6;26(55):7611-7619.
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