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NU2058

  Cat. No.:  DC10734   Featured
Chemical Structure
161058-83-9
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More than 5000 active chemicals with high quality for research!
Field of application
NU2058 is a guanine-based CDK inhibitor with IC50 of 17 μM and 26 μM for CDK2 and CDK1.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 161058-83-9
Synonyms: NU 2058,NU-2058,NU2058
SMILES: C1(COC2N=C(N)N=C3C=2N=CN3)CCCCC1
Formula: C12H17N5O
M.Wt: 247.3
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: NU2058 is a guanine-based CDK inhibitor with IC50 of 17 μM and 26 μM for CDK2 and CDK1.
Target: CDK2:17 μM (IC50) CDK1:26 μM (IC50)
In Vitro: NU2058 is a competitive inhibitor of CDK2 with respect to ATP (Ki value CDK2, 12 3 μM) that binds in the ATP binding pocket in a different orientation from other purine-based inhibitors, including olomoucine and roscovotine. NU2058 is the lead compound in a structure-based drug discovery program to develop more potent and selective CDK inhibitors.
References: [1]. Rigas AC, et al. Therapeutic potential of CDK inhibitor NU2058 in androgen-independent prostate cancer. Oncogene. 2007 Dec 6;26(55):7611-7619.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
Cat. No. Product name Field of application
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