Pyridostatin trifluoroacetate salt Datasheet DC Chemicals
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Cat.No DC8091
Name Pyridostatin trifluoroacetate salt

Chemical Properties

CAS 1085412-37-8
Formula C31H32N8O5.XC2HF3O2
MW 596.63(free base)
Storage 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological activity

Description
Target:
In Vivo
In Vitro Pyridostatin is a G-quadruplexe stabilizer, with a Kd of 490 nM[1]. Pyridostatin (PDS) shows neurotoxic activity against primary cortical neurons at 0.01-5 μM, causes DNA double-strand breaks (DSBs) at 1 μM, downregulates BRCA1 in neurons at 1, 2 or 5 μM[2]. Pyridostatin interacts with G-quadruplex motifs in SRC and alters mRNA levels of damaged genes[3].
Kinase Assay
Cell Assay
Animal Administration

References

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