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Pyridostatin trifluoroacetate salt

  Cat. No.:  DC8091   Featured
Chemical Structure
1085412-37-8
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Field of application
Pyridostatin stabilizes G-quadruplexes, targeting the proto-oncogene SRC and telomeric G-quadruplexes, inducing DNA damage and cell-cycle arrest.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 1085412-37-8
Chemical Name: 4-(2-Aminoethoxy)-N2,N6-bis[4-(2-aminoethoxy)-2-quinolinyl]-2,6-pyridinedicarboxamide
Synonyms: RR82,RR-82
SMILES: C(C(NC1C=C(OCCN)C2C(N=1)=CC=CC=2)=O)1=NC(C(NC2C=C(OCCN)C3C(N=2)=CC=CC=3)=O)=CC(OCCN)=C1.C(O)(=O)C(F)(F)F
Formula: C31H32N8O5.XC2Hf3O2
M.Wt: 596.63(free base)
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: Pyridostatin is a G-quadruplexe stabilizer, with a Kd of 490 nM.
In Vitro: Pyridostatin is a G-quadruplexe stabilizer, with a Kd of 490 nM[1]. Pyridostatin (PDS) shows neurotoxic activity against primary cortical neurons at 0.01-5 μM, causes DNA double-strand breaks (DSBs) at 1 μM, downregulates BRCA1 in neurons at 1, 2 or 5 μM[2]. Pyridostatin interacts with G-quadruplex motifs in SRC and alters mRNA levels of damaged genes[3].
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
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