SPEN-IN-1 Datasheet DC Chemicals

Description	SPEN-IN-1 (compound X1) is an inhibitor of SPEN which is a protein factor with a Kd value of 47 nM. SPEN-IN-1 has high selectivity for RepA, a 431-nucleotide domain in Xist (a non-coding RNA prototype) that comprises 8.5 units of a GC-rich motif responsible for gene silencing.
Cat.No	DC58301
Name	SPEN-IN-1

Chemical Properties

CAS	2863686-82-0
Formula	C27H20N4O
MW	416.47
Storage	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

References

Rodrigo Aguilar et al. Targeting Xist with compounds that disrupt RNA structure and X inactivation. Nature, 2022, doi:10.1038/s41586-022-04537-z.

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