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SPEN-IN-1

  Cat. No.:  DC58301   Featured
Chemical Structure
2863686-82-0
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Field of application
SPEN-IN-1 (compound X1) is an inhibitor of SPEN which is a protein factor with a Kd value of 47 nM. SPEN-IN-1 has high selectivity for RepA, a 431-nucleotide domain in Xist (a non-coding RNA prototype) that comprises 8.5 units of a GC-rich motif responsible for gene silencing.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 2863686-82-0
Chemical Name: SPEN-IN-1
Synonyms: Cmopound X1
SMILES: C1=CC=CC=C1COC1=CC(C2=CC=C3NN=C(C4=NC5C=CC=CC=5N4)C3=C2)=CC=C1
Formula: C27H20N4O
M.Wt: 416.47
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication: Targeting Xist with compounds that disrupt RNA structure and X inactivation--Nature,2022-Mar-30
Description: Compound X1 (Xist) X1 (Xist) binds the non-coding RNA prototype Xist, specifically the RepA motif, with Kd of 0.4 μM. X1 binding reduces the conformational space of RepA, displaces cognate interacting protein factors (PRC2 and SPEN), suppresses histone H3K27 trimethylation, and blocks initiation of X-chromosome inactivation.
References: Rodrigo Aguilar et al. Targeting Xist with compounds that disrupt RNA structure and X inactivation. Nature, 2022, doi:10.1038/s41586-022-04537-z.
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2018-0101
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